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Morishita Laboratory for Developing Minds

May 20th, 2021

5/20/2021

 
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​Dr. Ting-Jiun Chen, PhD, receives a Career-Starter Research Grant for 2021-2022 from the Knights Templar Eye Foundation.

NEW YORK –  May 20, 2021 /Press Release/  –– 

Mount Sinai School of Medicine researcher Ting-Jiun Chen, PhD, has received a Career-Starter Research Grant for 2021-2022 from the Knights Templar Eye Foundation.

Dr. Chen, Postdoctoral Fellow in the labs of Dr. Hirofumi Morishita MD PhD at the  Friedman Brain Institute and the Mindich Child Health and Development Institute at Mount Sinai School of Medicine, was awarded the grant for her work entitled, "Discover novel neuromodulatory therapeutic target for recovery from Amblyopia". The grant of $70,000 was given to Dr. Chen on May 20h.

"Our goal is to 
discover new regulatory mechanisms of plasticity to provide therapeutic targets and drugs to re-open the plasticity in the adult brain for recovery from Amblyopia" said Dr. Chen. "We will leverage new understanding of the cell-type specific cortical plasticity mechanism to identify drugs that putatively enhance cortical plasticity".

A 'lazy eye' or monocular cataract early in life results in an enduring loss of visual acuity (amblyopia) reflecting aberrant circuit remodeling within the primary visual cortex. Amblyopia affects two to four percent of the human population and exhibits little recovery in adulthood. Successful therapies for Amblyopia are therefore contingent on understanding the mechanism of adult brain plasticity.

If successful, the proposed project will identify small molecules with ability to rescue Amblyopia through cell-type specific mechanisms.

The Knights Templar Eye Foundation supports research that can help launch the careers of clinical or basic researchers committed to the prevention and cure of potentially blinding diseases in infants and children. They support clinical or basic research on conditions that can or may eventually be treated or prevented.
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April 2021

4/28/2021

 
Congratulations to our PhD student Kevin Norman for his successful thesis defense "Frontal-Sensory Cortical Projections Regulate Cognitive Control of Attentional Behavior in mice" !!
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May 2020

5/28/2020

 
Congratulations to our PhD student Lucy Bicks for her successful thesis defense, and a receipt of the Thesis with the Distinction Award for 2020!
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April 2020

4/24/2020

 
Congrats to our PhD student Lucy Bicks for being awarded Hausfeld Memorial Award for a senior graduate student at Mt. Sinai who demonstrated outstanding scientific contribution!
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February 2020

2/22/2020

 
Congratulations to our PhD student Lucy Bicks for her paper titled "Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior published in Nature Communications
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August 2019

8/2/2019

 
Congratulations to our PhD student Masato Sadahiro for his successful defense of his thesis "Restoration of Cortical Plasticity through Nicotinic Modulation of Inhibitory Circuits"
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July 2019

7/15/2019

 
Congratulation to our PhD student Kevin Norman who was awarded a NRSA individual predoctoral fellowship from NIMH to study prefrontal top-down cortico-cortical circuits in control of attentional behavior !

May 2019

5/14/2019

 
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Milo Smith, PhD, receives a Career-Starter Research Grant for 2019-2020 from the Knights Templar Eye Foundation.
NEW YORK –  May 14, 2019 /Press Release/  –– 

Mount Sinai School of Medicine researcher Milo Smith, PhD, has received a Career-Starter Research Grant for 2017-2018 from the Knights Templar Eye Foundation.

Dr. Smith, Postdoctoral Fellow in the labs of Dr. Hirofumi Morishita MD PhD and Dr. Joel Dudley at the  Friedman Brain Institute and the Mindich Child Health and Development Institute at Mount Sinai School of Medicine, was awarded the grant for his work entitled, "Establishing a high-throughput screen to discover drug candidates to treat Amblyopia". The grant of $65,000 was given to Dr. Smith on May 14th.

"Our goal is to develop and apply an in vitro model of critical period circuitry as a high-throughout screen for drug modulators of plasticity" said Dr. Smith. "We will leverage new understanding of the cell-type specific high-throughput mouse primary culture screen to identify drugs that putatively enhance cortical plasticity".

A 'lazy eye' or monocular cataract early in life results in an enduring loss of visual acuity (amblyopia) reflecting aberrant circuit remodeling within the primary visual cortex. Amblyopia affects two to four percent of the human population and exhibits little recovery in adulthood. Successful therapies for Amblyopia are therefore contingent on understanding the mechanism of adult brain plasticity.

If successful, the proposed project will identify small molecules with ability to rescue Amblyopia through cell-type specific mechanisms, as well as set the stage to scale our approach to screen 1000s of drugs for their ability to treat Amblyopia.

The Knights Templar Eye Foundation supports research that can help launch the careers of clinical or basic researchers committed to the prevention and cure of potentially blinding diseases in infants and children. They support clinical or basic research on conditions that can or may eventually be treated or prevented.

May 2019

5/10/2019

 
Congratulations to our PhD student Michael Leventhal for being awarded 2019 BRAIN award for best Neuroscience graduate student. Congrats also to our PhD student Lucy Bicks who was selected to give a talk at FBI retreat.
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Sep 2018

10/22/2018

 
Congratulation to our PhD student Lucy Bicks who was awarded a NRSA individual predoctoral fellowship from NIMH to study juvenile prefrontal critical period for social behavior development !
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