• Home
  • Research Interest
  • Publications
  • Hiro Morishita
  • Lab Members
  • Lablog
  • Contact us
  • Links
Morishita Laboratory for Developing Minds

Publications



Representative Publications

Social Development

​
Yamamuro K, Bicks LK, Leventhal M, Im S, Kato D, Flanigan  ME, Garkun Y, Norman KJ, Caro K, Sadahiro M, Kullander K, Akbarian S, Russo SJ, and Morishita H
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice. 
Nature Neuroscience 31 Aug 2020. DOI : 10.1038/s41593-020-0695-6

​​Bicks LK, Yamamuro K, Flanigan ME, Kim JM, Kato D, Lucas EK, Koike H, Peng MS, Brady DM, Chandrasekaran S, Norman KJ, Smith M, Clem RL, Russo SJ, Akbarian S, and Morishita H
Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior. 
Nature Communications 2020 Feb 21, 
11, 1003 (2020)

Cognitive Development

Norman KJ, Riceberg JS, Koike H, Bateh, J., Lopez S, Caro, K., Kato D, Liang A, Yamamuro, K., Flanigan M, Nabel E, Brady, D., Cho, C., Riceberg, J., Sadahiro, M., Yoshitake K, Maccario P, Demars M, Waltrip L, Varga A, Russo SJ, Baxter MG, Shapiro, ML., Rudebeck, P., Morishita H. 
Post-error recruitment of frontal sensory cortical projections promotes attention in mice.
​Neuron  
February 19, 2021. DOI:https://doi.org/10.1016/j.neuron.2021.02.001​​

Falk EN, Norman, KJ., Garkun, Y., Demars, MP, Im, S., Taccheri G., Short, J., Caro, K., Lopez, S., Cho, C., Smith MR, Lin, H., Koike, H.,Bateh, J., Maccario, P., Waltrip, L., Janis, M., Morishita, H.
Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation.
Science Advances 
05 Mar 2021: Vol. 7, no. 10, eabe1527, DOI: 10.1126/sciadv.abe1527

Nabel E, Garkun Y, Koike H, Sadahiro M, Liang A, Norman KJ, Taccheri G, Demars M, Im S, Caro K, Lopez S, Bateh J, Hof PR, Clem E, Morishita H
Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice . 
Nature Communications 7 Aug 2020. 11: 3983 (2020) 

Visual Development

Sadahiro, M., Demars, MP., Burman, P., Yevoo, P., Zimmer, A., Morishita, H. 
Activation of somatostatin interneurons by nicotinic modulator Lypd6 enhances plasticity and functional recovery in the adult mouse visual cortex
Journal of Neuroscience 
28 May 2020; DOI: https://doi.org/10.1523/JNEUROSCI.1373-19.2020

​Sajo, M., Ellis-Davies, G.C., Morishita, H.
Lynx1 limits dendritic spine turnover in the adult visual cortex
Journal of Neuroscience 2016 Sep7, 36(36):9472-9478

Morishita, H., Miwa, JM., Heintz, N., Hensch, TK.. 
Lynx1, a cholinergic brake limits plasticity in adult visual cortex. 
Science 2010 Nov 26; 330(6008):1238-40. ​
​



​Full Publication List


2023

Vinogradov S, Chafee M, Lee E, Morishita H
Psychosis Spectrum Illnesses as Disorders of Prefrontal Critical Period Plasticity
Neuropsychopharmacology 2023. doi: 10.1038/s41386-022-01451-w. Review  


​2022
​
Norman KJ, Bateh J, Maccario P, Cho C, Caro K, Nishioka T, Koike H, Morishita H
Frontal-sensory cortical projections become dispensable for attentional performance upon a reduction of task demand in mice
Front Neurosci. 2022 Jan 11 doi: 10.3389/fnins.2021.775256​
​


2021​

Lepow L, Morishita H, Yehuda R.
Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy.
Front Neurosci. 2021 Sep 20;15:710004. doi: 10.3389/fnins.2021.710004. eCollection 2021. (Review)



​
Bicks LK, Peng M, Taub A, Akbarian S, Morishita H
An adolescent sensitive period for social dominance hierarchy plasticity is regulated by cortical plasticity modulators in mice
Frontiers in Neural Circuits 2021, doi: 10.3389/fncir.2021.676308




*Norman, K.J., *Koike H, McCraney, S.E., Garkun, Y, Bateh, J, Falk, E.N., Im, S, Caro, K, Demars, M.P., Morishita, H 
Chemogenetic suppression of anterior cingulate cortical neurons projecting to the visual cortex disrupts attentional behavior in mice 
Neuropsychopharmacology Reports 2021, doi.org/10.1002/npr2.12176



​
Falk EN, Norman, KJ., Garkun, Y., Demars, MP, Im, S., Taccheri G., Short, J., Caro, K., Lopez, S., Cho, C., Smith MR, Lin, H., Koike, H.,Bateh, J., Maccario, P., Waltrip, L., Janis, M., Morishita, H.
Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation.
Science Advances 
05 Mar 2021: Vol. 7, no. 10, eabe1527, DOI: 10.1126/sciadv.abe1527

    # Featured in Science mag, news wise, Bioengineer, Science news, Eurek Alert!, News Medical, Frontline Genomics
Picture

​ 
​Norman KJ, Riceberg JS, Koike H, Bateh, J., Lopez S, Caro, K., Kato D, Liang A, Yamamuro, K., Flanigan M, Nabel E, Brady, D., Cho, C., Riceberg, J., Sadahiro, M., Yoshitake K, Maccario P, Demars M, Waltrip L, Varga A, Russo SJ, Baxter MG, Shapiro, ML., Rudebeck, P., Morishita H. 
Post-error recruitment of frontal sensory cortical projections promotes attention in mice.
​
Neuron 
February 19, 2021. DOI:https://doi.org/10.1016/j.neuron.2021.02.001​​
​
   # Preview by
Markus Ullsperger and Oliver Stork 
     
"To err is (not only) human: Mechanisms of post-error attentional regulation illuminated in mice​"
      Neuron 
 Vol 109, Issue 7, P1074-1076, April  07, 2021

   ​# Press release Mount Sinai Researchers Uncover a Neural Pathway that is Critical to Correcting Behavioral Errors Relevant
      to Many Psychiatric Disorders
   # Featured in NIH NEI research news,  NeuroscienceNews, NewsWise, Medindia, Medical Press, Technology Networks, 
      Bioengineer.org, EurekAlert! , News Medical, Joiforme , MedLink Neurology, PharmaC.Top, HealthNewsDigest, 
      GlobeHealthNews, QS study, ScienceMission
Picture

​
Morishita H

A prefrontal social circuit vulnerable to juvenile social isolation
Neuropsychopharmacology 2021 (Hot topic) DOI : 10.1038/s41386-020-00821-6
​

​
​2020 

Campbell BC, Nabel EM, Murdock MH, Lao-Peregrin C, Tsoulfas P, Blackmore MG, Lee FS, Liston C, Morishita H, Petsko GA.
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.

Proc Natl Acad Sci U S A 2020 Nov 18:202000942. doi: 10.1073/pnas.2000942117.
​
​
Yamamuro K, Bicks LK, Leventhal M, Im S, Kato D, Flanigan  ME, Garkun Y, Norman KJ, Caro K, Sadahiro M, Kullander K, Akbarian S, Russo SJ, and Morishita H
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice. 

Nature Neuroscience 31 Aug 2020. DOI : 10.1038/s41593-020-0695-6
​​
     # Research Highlight "Testing Time Alone" by Sian Lewis. Nature Reviews Neuroscience 2020 
     # ​Press release "Researchers Discover a Specific Brain Circuit Damaged by Social Isolation During Childhood"
     # Featured in ScienceDaily, NewsWise, NeuroscienceNews, Home Health Choice,  Technology Networks, MDNewsDaily, 
        Open Access Government, SciSeek, Health Units, Scientist Study,  Small Tech News,  Medical X Press, EurekAlert!
, Slash Gear,
        Big Think, Psychology Today
Picture


​
Nabel E, Garkun Y, Koike H, Sadahiro M, Liang A, Norman KJ, Taccheri G, Demars M, Im S, Caro K, Lopez S, Bateh J, Hof PR, Clem E, Morishita H

Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice . 
Nature Communications 7 Aug 2020. 11: 3983 (2020) 
Picture


​
​Bicks LK, Yamamuro K, Flanigan ME, Kim JM, Kato D, Lucas EK, Koike H, Peng MS, Brady DM, Chandrasekaran S, Norman KJ, Smith M, Clem RL, Russo SJ, Akbarian S, and Morishita H
Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior. 
Nature Communications 2020 Feb 21, 
11, 1003 (2020)

    ​ #  Faculty Opinions Recommendation by Dr. Hailan Hu.  09 Oct 2020; 10.3410/f.737407081.793578753
     #  Social Isolation during adolescence drives long-term disruptions in social behavior
     #  Featured article in Neuroscience News.Com, Article in Bio News Central
Picture


​
​Sadahiro, M., Demars, MP., Burman, P., Yevoo, P., Zimmer, A., Morishita, H. 
Activation of somatostatin interneurons by nicotinic modulator Lypd6 enhances plasticity and functional recovery in the adult mouse visual cortex
Journal of Neuroscience 
28 May 2020; DOI: https://doi.org/10.1523/JNEUROSCI.1373-19.2020
Picture


​Smith M, Yevoo P, Sadahiro M, 
 Readhead B, Kidd B, Dudley J*, Morishita H (* corresponding authors)
Systematic analysis of environmental chemicals that dysregulate critical period plasticity-related gene expression reveals common pathways that mimic immune response to pathogen.
Neural Plasticity 
 2020 May 5;2020:1673897. doi: 10.1155/2020/1673897. eCollection 2020.  
​
​

 

Picture

2019

Peña CJ, Smith M, Ramakrishnan A, Cates HM, Bagot RC, Kronman HG, Patel B, Chang AB, Purushothaman I, Dudley J, Morishita H, Shen L, Nestler EJ.
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice.
Nature Communications 2019 Nov 8;10(1):5098. doi: 10.1038/s41467-019-13085-6. PubMed


Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ
Synergistic effects of common schizophrenia risk variants.
Nature Genetics 2019 Sep 23. doi: 10.1038/s41588-019-0497-5. PubMed

Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V,  Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M.
CSF-1 controls cerebellar microglia and is required for motor function and social interaction.
Journal of Experimental Medicine 2019 Jul 26. pii: jem.20182037. doi: 10.1084/jem.20182037. PubMed


Morishita, H*. Vinogradov, S*. (* corresponding authors) 
Neuroplasticity and dysplasticity processes in Schizophrenia
Schizophrenia Research 2019 Mar 28. pii: S0920-9964(19)30090-8. PubMed


2018

Smith M, Readhead B, Dudley J, Morishita H
Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder.
Schizophrenia Research 2018 Nov 12th
, 
 pii: S0920-9964(18)30623-6. PubMed

Smith M, Yevoo P, Sadahiro M, Arora M, Dudley J, Morishita H
Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity.
Scientific Reports
Nov 6;8(1):16388. doi: 10.1038/s41598-018-34592-4, 2018. PubMed

Smith M
, Glicksberg B, Li L, Chen R, *Morishita H, *Dudley J (* corresponding authors)
Loss-of-function of neuroplasticity-related genes confers risk for human neurodevelopmental disorders.

Pac Symp Biocomput 2018 23:68-79. PubMed


2017


Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.
Nature Genetics 2017 Jul 3. doi: 10.1038/ng.3906. PubMed 


Steullet, P., Cabungcal, J., Coyle, J., Didriksen, M., Gill, K., Grace, A., Hensch, T., LaMantia, A., Lindemann, L., Maynard, T., Meyer, U., Morishita, H., O'Donnell, P., Puhl, M., Cuenod, M., Do, KQ. 
Oxidative stress-driven parvalbumin interneuron impairment as a core mechanism in models of psychiatric disorders.
Molecular Psychiatry 2017 
Jul;22(7):936-943. PubMed

Morishita, H., Arora, M.
Tooth-matrix biomarkers to reconstruct critical periods of brain plasticity.
Trends in Neurosciences 2017. Jan 27; 40 (1):1-3. Pubmed 
      # Video clip: Tooth Biomarkers Reconstruct Brain Plasticity  

Smith, M., Burman, P., Sadahiro, M., Kidd, B., Dudley, J., Morishita, H.
Integrative analysis of disease signatures shows inflammation disrupts juvenile experience-dependent cortical plasticity
eNeuro 2017 Jan 18. 3 (6). Pubmed 

​
2016

Sadahiro, M
., Sajo, M., Morishita, H.
Nicotinic regulaiton of experience-dependent plasticity in visual cortex
Journal of Physiology-Paris 2016 Nov 10th, Review. Pubmed

Sajo, M., Ellis-Davies, G.C., Morishita, H.
Lynx1 limits dendritic spine turnover in the adult visual cortex
Journal of Neuroscience 2016 Sep7, 36(36):9472-9478 Pubmed

Mitchell, A.C., Javidfar, B., Bicks, L.K., Neve, R., Garbett, K., Lander, S.S., Mirnics, K., Morishita,H., Wood, M.A., Jiang, Y., Gaisler-Salomon, I., Akbarian, S. 
Longitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal Cortex.
Nature Communications 2016 Sep 6;7:12743. PubMed

Lucas, E.K., Jegarl, A.M., Morishita, H., Clem, R.L.
Multimodal and site-specific plasticity of amygdala parvalbumin interneurons after fear learning
Neuron 2016 2016 Aug 3;91(3):629-43. PubMed

Koike, H., Demars, M.P., Short, J.A., Nabel, E.M., Akbarian, S., Baxter, M.G., Morishita, H. 

Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse. 
Neuropsychopharmacology 2016. Mar, 41 (4) 1014-23, doi: 10.1038/npp.2015.229. PubMed


2015

Bicks, L., Koike, H., Akbarian, S., Morishita,H. 
Prefrontal cortex and social cognition in mouse and man
Frontiers in Psychology.  Front. Psychol. | doi: 10.3389/fpsyg.2015.01805. Review. PubMed

Bukhari, N., Burman, P., Hussein, A., Demars, M.P., Sadahiro, M., Brady, D., Tsirka, S.E., Russo, S.J., Morishita, H. 

Unmasking proteolytic activity for adult visual cortex plasticity by the removal of Lynx1. 
Journal of Neuroscience 2015. Sep 16;35(37):12693-702. PubMed

Morishita, H., Kundakovic, M., Bicks, L., Mitchell, A., Akbarian, S. 
Interneuron Epigenomes duing the Critical Period of Cortical Plasticity: Implications for Schizophrenia.

Neurobiology of Learning and Memory. 2015 Oct;124:104-10. Review. PubMed

Morishita, H., Cabungcal, J., Chen, Y., Do, KQ., Hensch, TK.  
Prolonged period of cortical plasticity upon redox dysregulation in fast-spiking interneurons. 
Biological Psychiatry 2015  Sep 15;78(6):396-402. PubMed 


2014

Demars, MP., Morishita, H. 

Cortical parvalbumin and somatostatin GABA neurons express distinct endogenous modulators of nicotinic acetylcholine receptors. Molecular Brain 2014  Oct 31;7(1):75. PubMed


2013

Nabel E, Morishita H. 

Regulating Critical Period Plasticity: Insight from the Visual System to Fear Circuitry for Therapeutic Interventions.  
Front. Psychiatry  2013 Nov 11: 4: 146. Review PubMed

Sajo, M., Morishita, H. 

Critical Period Mechanisms: Implication for Neurodevelopmental and Psychiatric Disorders. 
Brain and Nerve 2013; 65(10) 1159-66. Review PubMed

Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQ. 

Perineuronal nets protect fast-spiking interneurons against oxidative stress. 
Proc Natl Acad Sci U S A. 2013 May 13. 110 (22) 9130-5: PubMed

   # Safety Net: Perineuronal Nets Protect Interneurons Linked to Schizophrenia
   Research News in Schizophrenia Research Forum
 # Damaged Protective ‘Net’ May Cause Malfunction in Brain Cells in Schizophrenia
      Discoveries in Brain & Behavior Research Foundation

Morishita, H. 

Molecular Strategies for Recovery from Amblyopia. 
Ophthalmology 2013; 55(1) 23-28. Review


2012

Morishita, H. 

Cholinergic contribution on visual cortex plasticity. 
Clinical Neuroscience 2012; 30(6) 649-651. Review

Morishita, H. 

Molecularly targeted therapeutic strategies for Amblyopia 
NeuroOphthalmol 2012; 29(4) 389-395. Review


2010-2006

Morishita, H., Miwa, JM., Heintz, N., Hensch, TK.. 

Lynx1, a cholinergic brake limits plasticity in adult visual cortex. 
Science 2010 Nov 26; 330(6008):1238-40. view in: PubMed

   # Perspective by Higley MJ, Strittmatter SM. 
       Science. 2010 Nov 26; 330(6008):1189-90.
   # Editor’s Choice by Hines PJ. Science Signaling
       2010 Nov 30
   # Understanding the brain’s “Brake Pedal” in Neural
        Plasticity. Scientific American. 2011 Feb 22.   
   # Removing an Endogenous Prototoxin Restores Vision. 
        Harvard MCB News. 2010 Dec 9.
   # Alzheimer’s drugs for “lazy eye”? 
        Children’s Hospital Boston’s science and 
        clinical innovation blog. 2010 Dec 16.
   # Supported by the James S. McDonnell Foundation 
       “Recovery from Amblyopia” network

Morishita, H., Hensch, TK. 

Critical period revisited: impact on vision. 
Current Opinion in Neurobiology. 2008 Feb; 18(1):101-7. Review. view in: PubMed

Morishita, H.*, Yagi, T.*. (*co-corresponding authors) 

Protocadherin family: diversity, structure, and function. 
Current Opinion in Cell Biology. 2007 Oct; 19(5):584-92. Review. view in: PubMed

Morishita, H.*, Umitsu, M.*, Murata, Y., Shibata, N., Udaka, K., Higuchi, Y., Akutsu, H., Yamaguchi T, Yagi, T., Ikegami, T. 

Structure of the cadherin-related neuronal receptor/protocadherin-alpha first extracellular cadherin domain reveals diversity across cadherin families. 
Journal of Biological Chemistry. 2006 Nov 3; 281(44):33650-63. view in: PubMed 
 # Evaluated by Faculty of 1000 Biology

​
2005-2001

Umitsu, M.*,Morishita, H.*, Murata, Y., Udaka, K., Akutsu, H., Yagi, T., Ikegami, T. (* equal first authors) 

1H, 13C and 15N resonance assignments of the first cadherin domain of Cadherin related neuronal receptor/Protocadherin α. 
Journal of Biomolecular NMR. 2005,  Apr; 31(4):365-6. view in: PubMed

Morishita, H., Murata, Y., Esumi, S., Hamada, S., Yagi, T. 

CNR/Pcdhα family in subplate neurons, and developing cortical connectivity. 
Neuroreport. 2004 Dec 3; 15(17): 2595-2599. view in: PubMed

Morishita, H., Kawaguchi, M., Murata, Y., Seiwa, C., Hamada, S., Asou, H., Yagi, T. 

Myelination triggers local loss of axonal CNR/Protocadherinα family expression. 
European Journal of Neuroscience. 2004 Dec 2; 20(11): 2843-2847. view in PubMed

Murata, Y., Hamada, S., Morishita, H., Mutoh, T., Yagi, T. 

Interaction with Protocadherin-g regulates the cell-surface expression of Protocadherin-α. 
Journal of Biological Chemistry. 2004 Nov 19;279(47): 49508-49516.  view in PubMed

Tada, M., Senzaki, K., Tai, Y., Morishita, H., Tanaka, Y., Murata, Y., Ishii, Y., Asakawa, S., Shimizu, N., Sugino, H., Yagi, T. 

Genomic organization and transcripts of the zebrafish Protocadherin genes. 
Gene. 2004 Oct 13; 340(2):197-211. view in PubMed

Morishita, H., Makishima, T., Kaneko, C., Lee, YS., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K., Nakayama, KI. 

Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. 
Biochemical and Biophysical Research Communications. 2001 Jun 1; 284(1):142-9. view in PubMed

Powered by Create your own unique website with customizable templates.