Publications

2019

Sadahiro, M.*, Demars, MP.*, Burman, P., Yevoo, P., Smith, MR., Zimmer, A., Morishita, H. (* equal contribution)
Activation of Somatostatin Inhibitory Neurons by Lypd6-nAChRα2 System Restores Juvenile-like Plasticity in Adult Visual Cortex.
BioRxiv doi: https://doi.org/10.1101/155465 (Pre-print).

Peña CJ, Smith M, Ramakrishnan A, Cates HM, Bagot RC, Kronman HG, Patel B, Chang AB, Purushothaman I, Dudley J, Morishita H, Shen L, Nestler EJ.
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice.
Nature Communications 2019 Nov 8;10(1):5098. doi: 10.1038/s41467-019-13085-6. PubMed

Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ
Synergistic effects of common schizophrenia risk variants.
Nature Genetics 2019 Sep 23. doi: 10.1038/s41588-019-0497-5. PubMed

Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M.
CSF-1 controls cerebellar microglia and is required for motor function and social interaction.
Journal of Experimental Medicine 2019 Jul 26. pii: jem.20182037. doi: 10.1084/jem.20182037. PubMed

Morishita, H*. Vinogradov, S*. (* corresponding authors)
Neuroplasticity and dysplasticity processes in Schizophrenia
Schizophrenia Research 2019 Mar 28. pii: S0920-9964(19)30090-8. PubMed

2018

Smith M, Readhead B, Dudley J, Morishita H
Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder.
Schizophrenia Research 2018 Nov 12th,  pii: S0920-9964(18)30623-6. PubMed

Smith M, Yevoo P, Sadahiro M, Arora M, Dudley J, Morishita H
Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity.
Scientific Reports Nov 6;8(1):16388. doi: 10.1038/s41598-018-34592-4, 2018. PubMed

Smith M, Glicksberg B, Li L, Chen R, *Morishita H, *Dudley J (* corresponding authors)
Loss-of-function of neuroplasticity-related genes confers risk for human neurodevelopmental disorders.
Pac Symp Biocomput 2018 23:68-79. PubMed

2017

Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.
Nature Genetics 2017 Jul 3. doi: 10.1038/ng.3906. PubMed

Steullet, P., Cabungcal, J., Coyle, J., Didriksen, M., Gill, K., Grace, A., Hensch, T., LaMantia, A., Lindemann, L., Maynard, T., Meyer, U., Morishita, H., O'Donnell, P., Puhl, M., Cuenod, M., Do, KQ.
Oxidative stress-driven parvalbumin interneuron impairment as a core mechanism in models of psychiatric disorders.
Molecular Psychiatry 2017 Jul;22(7):936-943. PubMed

Morishita, H., Arora, M.
Tooth-matrix biomarkers to reconstruct critical periods of brain plasticity.
Trends in Neurosciences 2017. Jan 27; 40 (1):1-3. Pubmed
   # Video clip: Tooth Biomarkers Reconstruct Brain Plasticity

Smith, M., Burman, P., Sadahiro, M., Kidd, B., Dudley, J., Morishita, H.
Integrative analysis of disease signatures shows inflammation disrupts juvenile experience-dependent cortical plasticity
eNeuro 2017 Jan 18. 3 (6). Pubmed

2016

Sadahiro, M., Sajo, M., Morishita, H.
Nicotinic regulaiton of experience-dependent plasticity in visual cortex
Journal of Physiology-Paris 2016 Nov 10th, Review. Pubmed

Sajo, M., Ellis-Davies, G.C., Morishita, H.
Lynx1 limits dendritic spine turnover in the adult visual cortex
Journal of Neuroscience 2016 Sep7, 36(36):9472-9478 Pubmed

Mitchell, A.C., Javidfar, B., Bicks, L.K., Neve, R., Garbett, K., Lander, S.S., Mirnics, K., Morishita,H., Wood, M.A., Jiang, Y., Gaisler-Salomon, I., Akbarian, S.
Longitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal Cortex.
Nature Communications 2016 Sep 6;7:12743. PubMed

Lucas, E.K., Jegarl, A.M., Morishita, H., Clem, R.L.
Multimodal and site-specific plasticity of amygdala parvalbumin interneurons after fear learning
Neuron 2016 2016 Aug 3;91(3):629-43. PubMed

Koike, H., Demars, M.P., Short, J.A., Nabel, E.M., Akbarian, S., Baxter, M.G., Morishita, H.
Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse.
Neuropsychopharmacology 2016. Mar, 41 (4) 1014-23, doi: 10.1038/npp.2015.229. PubMed

2015

Bicks, L., Koike, H., Akbarian, S., Morishita,H.
Prefrontal cortex and social cognition in mouse and man
Frontiers in Psychology. Front. Psychol. | doi: 10.3389/fpsyg.2015.01805. Review. PubMed

Bukhari, N., Burman, P., Hussein, A., Demars, M.P., Sadahiro, M., Brady, D., Tsirka, S.E., Russo, S.J., Morishita, H.
Unmasking proteolytic activity for adult visual cortex plasticity by the removal of Lynx1.
Journal of Neuroscience 2015. Sep 16;35(37):12693-702. PubMed

Morishita, H., Kundakovic, M., Bicks, L., Mitchell, A., Akbarian, S.
Interneuron Epigenomes duing the Critical Period of Cortical Plasticity: Implications for Schizophrenia.
Neurobiology of Learning and Memory. 2015 Oct;124:104-10. Review. PubMed

Morishita, H., Cabungcal, J., Chen, Y., Do, KQ., Hensch, TK.
Prolonged period of cortical plasticity upon redox dysregulation in fast-spiking interneurons.
Biological Psychiatry 2015  Sep 15;78(6):396-402. PubMed

2014

Demars, MP., Morishita, H.
Cortical parvalbumin and somatostatin GABA neurons express distinct endogenous modulators of nicotinic acetylcholine receptors. Molecular Brain 2014  Oct 31;7(1):75. PubMed

2013

Nabel E, Morishita H.
Regulating Critical Period Plasticity: Insight from the Visual System to Fear Circuitry for Therapeutic Interventions.
Front. Psychiatry 2013 Nov 11: 4: 146. Review PubMed

Sajo, M., Morishita, H.
Critical Period Mechanisms: Implication for Neurodevelopmental and Psychiatric Disorders.
Brain and Nerve 2013; 65(10) 1159-66. Review PubMed

Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQ.
Perineuronal nets protect fast-spiking interneurons against oxidative stress.
Proc Natl Acad Sci U S A. 2013 May 13. 110 (22) 9130-5: PubMed

# Safety Net: Perineuronal Nets Protect Interneurons Linked to Schizophrenia
　　 Research News in Schizophrenia Research Forum
　# Damaged Protective ‘Net’ May Cause Malfunction in Brain Cells in Schizophrenia
Discoveries in Brain & Behavior Research Foundation

Morishita, H.
Molecular Strategies for Recovery from Amblyopia.
Ophthalmology 2013; 55(1) 23-28. Review

2012

Morishita, H.
Cholinergic contribution on visual cortex plasticity.
Clinical Neuroscience 2012; 30(6) 649-651. Review

Morishita, H.
Molecularly targeted therapeutic strategies for Amblyopia
NeuroOphthalmol 2012; 29(4) 389-395. Review

2010-2006

Morishita, H., Miwa, JM., Heintz, N., Hensch, TK..
Lynx1, a cholinergic brake limits plasticity in adult visual cortex.
Science 2010 Nov 26; 330(6008):1238-40. view in: PubMed

# Perspective by Higley MJ, Strittmatter SM.
Science. 2010 Nov 26; 330(6008):1189-90.
# Editor’s Choice by Hines PJ. Science Signaling
2010 Nov 30
# Understanding the brain’s “Brake Pedal” in Neural
  Plasticity. Scientific American. 2011 Feb 22.
# Removing an Endogenous Prototoxin Restores Vision.
Harvard MCB News. 2010 Dec 9.
# Alzheimer’s drugs for “lazy eye”?
Children’s Hospital Boston’s science and
clinical innovation blog. 2010 Dec 16.
# Supported by the James S. McDonnell Foundation
“Recovery from Amblyopia” network

Morishita, H., Hensch, TK.
Critical period revisited: impact on vision.
Current Opinion in Neurobiology. 2008 Feb; 18(1):101-7. Review. view in: PubMed

Morishita, H.*, Yagi, T.*. (*co-corresponding authors)
Protocadherin family: diversity, structure, and function.
Current Opinion in Cell Biology. 2007 Oct; 19(5):584-92. Review. view in: PubMed

Morishita, H.*, Umitsu, M.*, Murata, Y., Shibata, N., Udaka, K., Higuchi, Y., Akutsu, H., Yamaguchi T, Yagi, T., Ikegami, T.
Structure of the cadherin-related neuronal receptor/protocadherin-alpha first extracellular cadherin domain reveals diversity across cadherin families.
Journal of Biological Chemistry. 2006 Nov 3; 281(44):33650-63. view in: PubMed
# Evaluated by Faculty of 1000 Biology

2005-2001

Umitsu, M.*,Morishita, H.*, Murata, Y., Udaka, K., Akutsu, H., Yagi, T., Ikegami, T.　(* equal first authors)
1H, 13C and 15N resonance assignments of the first cadherin domain of Cadherin related neuronal receptor/Protocadherin α.
Journal of Biomolecular NMR. 2005, Apr; 31(4):365-6. view in: PubMed

Morishita, H., Murata, Y., Esumi, S., Hamada, S., Yagi, T.
CNR/Pcdhα family in subplate neurons, and developing cortical connectivity.
Neuroreport. 2004 Dec 3; 15(17): 2595-2599. view in: PubMed

Morishita, H., Kawaguchi, M., Murata, Y., Seiwa, C., Hamada, S., Asou, H., Yagi, T.
Myelination triggers local loss of axonal CNR/Protocadherinα family expression.
European Journal of Neuroscience. 2004 Dec 2; 20(11): 2843-2847. view in PubMed

Murata, Y., Hamada, S., Morishita, H., Mutoh, T., Yagi, T.
Interaction with Protocadherin-g regulates the cell-surface expression of Protocadherin-α.
Journal of Biological Chemistry. 2004 Nov 19;279(47): 49508-49516. view in PubMed

Tada, M., Senzaki, K., Tai, Y., Morishita, H., Tanaka, Y., Murata, Y., Ishii, Y., Asakawa, S., Shimizu, N., Sugino, H., Yagi, T.
Genomic organization and transcripts of the zebrafish Protocadherin genes.
Gene. 2004 Oct 13; 340(2):197-211. view in PubMed

Morishita, H., Makishima, T., Kaneko, C., Lee, YS., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K., Nakayama, KI.
Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice.
Biochemical and Biophysical Research Communications. 2001 Jun 1; 284(1):142-9. view in PubMed