Publications
Representative Publications
Social Development
Yamamuro K, Bicks LK, Leventhal M, Im S, Kato D, Flanigan ME, Garkun Y, Norman KJ, Caro K, Sadahiro M, Kullander K, Akbarian S, Russo SJ, and Morishita H
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice.
Nature Neuroscience 31 Aug 2020. DOI : 10.1038/s41593-020-0695-6
Bicks LK, Yamamuro K, Flanigan ME, Kim JM, Kato D, Lucas EK, Koike H, Peng MS, Brady DM, Chandrasekaran S, Norman KJ, Smith M, Clem RL, Russo SJ, Akbarian S, and Morishita H
Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior.
Nature Communications 2020 Feb 21, 11, 1003 (2020)
Cognitive Development
Norman KJ, Riceberg JS, Koike H, Bateh, J., Lopez S, Caro, K., Kato D, Liang A, Yamamuro, K., Flanigan M, Nabel E, Brady, D., Cho, C., Riceberg, J., Sadahiro, M., Yoshitake K, Maccario P, Demars M, Waltrip L, Varga A, Russo SJ, Baxter MG, Shapiro, ML., Rudebeck, P., Morishita H.
Post-error recruitment of frontal sensory cortical projections promotes attention in mice.
Neuron February 19, 2021. DOI:https://doi.org/10.1016/j.neuron.2021.02.001
Falk EN, Norman, KJ., Garkun, Y., Demars, MP, Im, S., Taccheri G., Short, J., Caro, K., Lopez, S., Cho, C., Smith MR, Lin, H., Koike, H.,Bateh, J., Maccario, P., Waltrip, L., Janis, M., Morishita, H.
Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation.
Science Advances 05 Mar 2021: Vol. 7, no. 10, eabe1527, DOI: 10.1126/sciadv.abe1527
Nabel E, Garkun Y, Koike H, Sadahiro M, Liang A, Norman KJ, Taccheri G, Demars M, Im S, Caro K, Lopez S, Bateh J, Hof PR, Clem E, Morishita H
Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice .
Nature Communications 7 Aug 2020. 11: 3983 (2020)
Visual Development
Sadahiro, M., Demars, MP., Burman, P., Yevoo, P., Zimmer, A., Morishita, H.
Activation of somatostatin interneurons by nicotinic modulator Lypd6 enhances plasticity and functional recovery in the adult mouse visual cortex
Journal of Neuroscience 28 May 2020; DOI: https://doi.org/10.1523/JNEUROSCI.1373-19.2020
Sajo, M., Ellis-Davies, G.C., Morishita, H.
Lynx1 limits dendritic spine turnover in the adult visual cortex
Journal of Neuroscience 2016 Sep7, 36(36):9472-9478
Morishita, H., Miwa, JM., Heintz, N., Hensch, TK..
Lynx1, a cholinergic brake limits plasticity in adult visual cortex.
Science 2010 Nov 26; 330(6008):1238-40.
Full Publication List
2023
Vinogradov S, Chafee M, Lee E, Morishita H
Psychosis Spectrum Illnesses as Disorders of Prefrontal Critical Period Plasticity
Neuropsychopharmacology 2023. doi: 10.1038/s41386-022-01451-w. Review
2022
Norman KJ, Bateh J, Maccario P, Cho C, Caro K, Nishioka T, Koike H, Morishita H
Frontal-sensory cortical projections become dispensable for attentional performance upon a reduction of task demand in mice
Front Neurosci. 2022 Jan 11 doi: 10.3389/fnins.2021.775256
2021
Lepow L, Morishita H, Yehuda R.
Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy.
Front Neurosci. 2021 Sep 20;15:710004. doi: 10.3389/fnins.2021.710004. eCollection 2021. (Review)
Bicks LK, Peng M, Taub A, Akbarian S, Morishita H
An adolescent sensitive period for social dominance hierarchy plasticity is regulated by cortical plasticity modulators in mice
Frontiers in Neural Circuits 2021, doi: 10.3389/fncir.2021.676308
*Norman, K.J., *Koike H, McCraney, S.E., Garkun, Y, Bateh, J, Falk, E.N., Im, S, Caro, K, Demars, M.P., Morishita, H
Chemogenetic suppression of anterior cingulate cortical neurons projecting to the visual cortex disrupts attentional behavior in mice
Neuropsychopharmacology Reports 2021, doi.org/10.1002/npr2.12176
Falk EN, Norman, KJ., Garkun, Y., Demars, MP, Im, S., Taccheri G., Short, J., Caro, K., Lopez, S., Cho, C., Smith MR, Lin, H., Koike, H.,Bateh, J., Maccario, P., Waltrip, L., Janis, M., Morishita, H.
Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation.
Science Advances 05 Mar 2021: Vol. 7, no. 10, eabe1527, DOI: 10.1126/sciadv.abe1527
# Featured in Science mag, news wise, Bioengineer, Science news, Eurek Alert!, News Medical, Frontline Genomics
Norman KJ, Riceberg JS, Koike H, Bateh, J., Lopez S, Caro, K., Kato D, Liang A, Yamamuro, K., Flanigan M, Nabel E, Brady, D., Cho, C., Riceberg, J., Sadahiro, M., Yoshitake K, Maccario P, Demars M, Waltrip L, Varga A, Russo SJ, Baxter MG, Shapiro, ML., Rudebeck, P., Morishita H.
Post-error recruitment of frontal sensory cortical projections promotes attention in mice.
Neuron February 19, 2021. DOI:https://doi.org/10.1016/j.neuron.2021.02.001
# Preview by Markus Ullsperger and Oliver Stork
"To err is (not only) human: Mechanisms of post-error attentional regulation illuminated in mice"
Neuron Vol 109, Issue 7, P1074-1076, April 07, 2021
# Press release Mount Sinai Researchers Uncover a Neural Pathway that is Critical to Correcting Behavioral Errors Relevant
to Many Psychiatric Disorders
# Featured in NIH NEI research news, NeuroscienceNews, NewsWise, Medindia, Medical Press, Technology Networks,
Bioengineer.org, EurekAlert! , News Medical, Joiforme , MedLink Neurology, PharmaC.Top, HealthNewsDigest,
GlobeHealthNews, QS study, ScienceMission
Morishita H
A prefrontal social circuit vulnerable to juvenile social isolation
Neuropsychopharmacology 2021 (Hot topic) DOI : 10.1038/s41386-020-00821-6
2020
Campbell BC, Nabel EM, Murdock MH, Lao-Peregrin C, Tsoulfas P, Blackmore MG, Lee FS, Liston C, Morishita H, Petsko GA.
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.
Proc Natl Acad Sci U S A 2020 Nov 18:202000942. doi: 10.1073/pnas.2000942117.
Campbell BC, Nabel EM, Murdock MH, Lao-Peregrin C, Tsoulfas P, Blackmore MG, Lee FS, Liston C, Morishita H, Petsko GA.
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.
Proc Natl Acad Sci U S A 2020 Nov 18:202000942. doi: 10.1073/pnas.2000942117.
Yamamuro K, Bicks LK, Leventhal M, Im S, Kato D, Flanigan ME, Garkun Y, Norman KJ, Caro K, Sadahiro M, Kullander K, Akbarian S, Russo SJ, and Morishita H
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice.
Nature Neuroscience 31 Aug 2020. DOI : 10.1038/s41593-020-0695-6
# Research Highlight "Testing Time Alone" by Sian Lewis. Nature Reviews Neuroscience 2020
# Press release "Researchers Discover a Specific Brain Circuit Damaged by Social Isolation During Childhood"
# Featured in ScienceDaily, NewsWise, NeuroscienceNews, Home Health Choice, Technology Networks, MDNewsDaily,
Open Access Government, SciSeek, Health Units, Scientist Study, Small Tech News, Medical X Press, EurekAlert!, Slash Gear,
Big Think, Psychology Today
A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice.
Nature Neuroscience 31 Aug 2020. DOI : 10.1038/s41593-020-0695-6
# Research Highlight "Testing Time Alone" by Sian Lewis. Nature Reviews Neuroscience 2020
# Press release "Researchers Discover a Specific Brain Circuit Damaged by Social Isolation During Childhood"
# Featured in ScienceDaily, NewsWise, NeuroscienceNews, Home Health Choice, Technology Networks, MDNewsDaily,
Open Access Government, SciSeek, Health Units, Scientist Study, Small Tech News, Medical X Press, EurekAlert!, Slash Gear,
Big Think, Psychology Today
Nabel E, Garkun Y, Koike H, Sadahiro M, Liang A, Norman KJ, Taccheri G, Demars M, Im S, Caro K, Lopez S, Bateh J, Hof PR, Clem E, Morishita H
Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice .
Nature Communications 7 Aug 2020. 11: 3983 (2020)
Bicks LK, Yamamuro K, Flanigan ME, Kim JM, Kato D, Lucas EK, Koike H, Peng MS, Brady DM, Chandrasekaran S, Norman KJ, Smith M, Clem RL, Russo SJ, Akbarian S, and Morishita H
Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior.
Nature Communications 2020 Feb 21, 11, 1003 (2020)
# Faculty Opinions Recommendation by Dr. Hailan Hu. 09 Oct 2020; 10.3410/f.737407081.793578753
# Social Isolation during adolescence drives long-term disruptions in social behavior
# Featured article in Neuroscience News.Com, Article in Bio News Central
Sadahiro, M., Demars, MP., Burman, P., Yevoo, P., Zimmer, A., Morishita, H.
Activation of somatostatin interneurons by nicotinic modulator Lypd6 enhances plasticity and functional recovery in the adult mouse visual cortex
Journal of Neuroscience 28 May 2020; DOI: https://doi.org/10.1523/JNEUROSCI.1373-19.2020
Smith M, Yevoo P, Sadahiro M, Readhead B, Kidd B, Dudley J*, Morishita H (* corresponding authors)
Systematic analysis of environmental chemicals that dysregulate critical period plasticity-related gene expression reveals common pathways that mimic immune response to pathogen.
Neural Plasticity 2020 May 5;2020:1673897. doi: 10.1155/2020/1673897. eCollection 2020.
2019
Peña CJ, Smith M, Ramakrishnan A, Cates HM, Bagot RC, Kronman HG, Patel B, Chang AB, Purushothaman I, Dudley J, Morishita H, Shen L, Nestler EJ.
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice.
Nature Communications 2019 Nov 8;10(1):5098. doi: 10.1038/s41467-019-13085-6. PubMed
Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ
Synergistic effects of common schizophrenia risk variants.
Nature Genetics 2019 Sep 23. doi: 10.1038/s41588-019-0497-5. PubMed
Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M.
CSF-1 controls cerebellar microglia and is required for motor function and social interaction.
Journal of Experimental Medicine 2019 Jul 26. pii: jem.20182037. doi: 10.1084/jem.20182037. PubMed
Morishita, H*. Vinogradov, S*. (* corresponding authors)
Neuroplasticity and dysplasticity processes in Schizophrenia
Schizophrenia Research 2019 Mar 28. pii: S0920-9964(19)30090-8. PubMed
2018
Smith M, Readhead B, Dudley J, Morishita H
Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder.
Schizophrenia Research 2018 Nov 12th, pii: S0920-9964(18)30623-6. PubMed
Smith M, Yevoo P, Sadahiro M, Arora M, Dudley J, Morishita H
Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity.
Scientific Reports Nov 6;8(1):16388. doi: 10.1038/s41598-018-34592-4, 2018. PubMed
Smith M, Glicksberg B, Li L, Chen R, *Morishita H, *Dudley J (* corresponding authors)
Loss-of-function of neuroplasticity-related genes confers risk for human neurodevelopmental disorders.
Pac Symp Biocomput 2018 23:68-79. PubMed
2017
Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.
Nature Genetics 2017 Jul 3. doi: 10.1038/ng.3906. PubMed
Steullet, P., Cabungcal, J., Coyle, J., Didriksen, M., Gill, K., Grace, A., Hensch, T., LaMantia, A., Lindemann, L., Maynard, T., Meyer, U., Morishita, H., O'Donnell, P., Puhl, M., Cuenod, M., Do, KQ.
Oxidative stress-driven parvalbumin interneuron impairment as a core mechanism in models of psychiatric disorders.
Molecular Psychiatry 2017 Jul;22(7):936-943. PubMed
Morishita, H., Arora, M.
Tooth-matrix biomarkers to reconstruct critical periods of brain plasticity.
Trends in Neurosciences 2017. Jan 27; 40 (1):1-3. Pubmed
# Video clip: Tooth Biomarkers Reconstruct Brain Plasticity
Smith, M., Burman, P., Sadahiro, M., Kidd, B., Dudley, J., Morishita, H.
Integrative analysis of disease signatures shows inflammation disrupts juvenile experience-dependent cortical plasticity
eNeuro 2017 Jan 18. 3 (6). Pubmed
2016
Sadahiro, M., Sajo, M., Morishita, H.
Nicotinic regulaiton of experience-dependent plasticity in visual cortex
Journal of Physiology-Paris 2016 Nov 10th, Review. Pubmed
Sajo, M., Ellis-Davies, G.C., Morishita, H.
Lynx1 limits dendritic spine turnover in the adult visual cortex
Journal of Neuroscience 2016 Sep7, 36(36):9472-9478 Pubmed
Mitchell, A.C., Javidfar, B., Bicks, L.K., Neve, R., Garbett, K., Lander, S.S., Mirnics, K., Morishita,H., Wood, M.A., Jiang, Y., Gaisler-Salomon, I., Akbarian, S.
Longitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal Cortex.
Nature Communications 2016 Sep 6;7:12743. PubMed
Lucas, E.K., Jegarl, A.M., Morishita, H., Clem, R.L.
Multimodal and site-specific plasticity of amygdala parvalbumin interneurons after fear learning
Neuron 2016 2016 Aug 3;91(3):629-43. PubMed
Koike, H., Demars, M.P., Short, J.A., Nabel, E.M., Akbarian, S., Baxter, M.G., Morishita, H.
Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse.
Neuropsychopharmacology 2016. Mar, 41 (4) 1014-23, doi: 10.1038/npp.2015.229. PubMed
2015
Bicks, L., Koike, H., Akbarian, S., Morishita,H.
Prefrontal cortex and social cognition in mouse and man
Frontiers in Psychology. Front. Psychol. | doi: 10.3389/fpsyg.2015.01805. Review. PubMed
Bukhari, N., Burman, P., Hussein, A., Demars, M.P., Sadahiro, M., Brady, D., Tsirka, S.E., Russo, S.J., Morishita, H.
Unmasking proteolytic activity for adult visual cortex plasticity by the removal of Lynx1.
Journal of Neuroscience 2015. Sep 16;35(37):12693-702. PubMed
Morishita, H., Kundakovic, M., Bicks, L., Mitchell, A., Akbarian, S.
Interneuron Epigenomes duing the Critical Period of Cortical Plasticity: Implications for Schizophrenia.
Neurobiology of Learning and Memory. 2015 Oct;124:104-10. Review. PubMed
Morishita, H., Cabungcal, J., Chen, Y., Do, KQ., Hensch, TK.
Prolonged period of cortical plasticity upon redox dysregulation in fast-spiking interneurons.
Biological Psychiatry 2015 Sep 15;78(6):396-402. PubMed
2014
Demars, MP., Morishita, H.
Cortical parvalbumin and somatostatin GABA neurons express distinct endogenous modulators of nicotinic acetylcholine receptors. Molecular Brain 2014 Oct 31;7(1):75. PubMed
2013
Nabel E, Morishita H.
Regulating Critical Period Plasticity: Insight from the Visual System to Fear Circuitry for Therapeutic Interventions.
Front. Psychiatry 2013 Nov 11: 4: 146. Review PubMed
Sajo, M., Morishita, H.
Critical Period Mechanisms: Implication for Neurodevelopmental and Psychiatric Disorders.
Brain and Nerve 2013; 65(10) 1159-66. Review PubMed
Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQ.
Perineuronal nets protect fast-spiking interneurons against oxidative stress.
Proc Natl Acad Sci U S A. 2013 May 13. 110 (22) 9130-5: PubMed
# Safety Net: Perineuronal Nets Protect Interneurons Linked to Schizophrenia
Research News in Schizophrenia Research Forum
# Damaged Protective ‘Net’ May Cause Malfunction in Brain Cells in Schizophrenia
Discoveries in Brain & Behavior Research Foundation
Morishita, H.
Molecular Strategies for Recovery from Amblyopia.
Ophthalmology 2013; 55(1) 23-28. Review
2012
Morishita, H.
Cholinergic contribution on visual cortex plasticity.
Clinical Neuroscience 2012; 30(6) 649-651. Review
Morishita, H.
Molecularly targeted therapeutic strategies for Amblyopia
NeuroOphthalmol 2012; 29(4) 389-395. Review
2010-2006
Morishita, H., Miwa, JM., Heintz, N., Hensch, TK..
Lynx1, a cholinergic brake limits plasticity in adult visual cortex.
Science 2010 Nov 26; 330(6008):1238-40. view in: PubMed
# Perspective by Higley MJ, Strittmatter SM.
Science. 2010 Nov 26; 330(6008):1189-90.
# Editor’s Choice by Hines PJ. Science Signaling
2010 Nov 30
# Understanding the brain’s “Brake Pedal” in Neural
Plasticity. Scientific American. 2011 Feb 22.
# Removing an Endogenous Prototoxin Restores Vision.
Harvard MCB News. 2010 Dec 9.
# Alzheimer’s drugs for “lazy eye”?
Children’s Hospital Boston’s science and
clinical innovation blog. 2010 Dec 16.
# Supported by the James S. McDonnell Foundation
“Recovery from Amblyopia” network
Morishita, H., Hensch, TK.
Critical period revisited: impact on vision.
Current Opinion in Neurobiology. 2008 Feb; 18(1):101-7. Review. view in: PubMed
Morishita, H.*, Yagi, T.*. (*co-corresponding authors)
Protocadherin family: diversity, structure, and function.
Current Opinion in Cell Biology. 2007 Oct; 19(5):584-92. Review. view in: PubMed
Morishita, H.*, Umitsu, M.*, Murata, Y., Shibata, N., Udaka, K., Higuchi, Y., Akutsu, H., Yamaguchi T, Yagi, T., Ikegami, T.
Structure of the cadherin-related neuronal receptor/protocadherin-alpha first extracellular cadherin domain reveals diversity across cadherin families.
Journal of Biological Chemistry. 2006 Nov 3; 281(44):33650-63. view in: PubMed
# Evaluated by Faculty of 1000 Biology
2005-2001
Umitsu, M.*,Morishita, H.*, Murata, Y., Udaka, K., Akutsu, H., Yagi, T., Ikegami, T. (* equal first authors)
1H, 13C and 15N resonance assignments of the first cadherin domain of Cadherin related neuronal receptor/Protocadherin α.
Journal of Biomolecular NMR. 2005, Apr; 31(4):365-6. view in: PubMed
Morishita, H., Murata, Y., Esumi, S., Hamada, S., Yagi, T.
CNR/Pcdhα family in subplate neurons, and developing cortical connectivity.
Neuroreport. 2004 Dec 3; 15(17): 2595-2599. view in: PubMed
Morishita, H., Kawaguchi, M., Murata, Y., Seiwa, C., Hamada, S., Asou, H., Yagi, T.
Myelination triggers local loss of axonal CNR/Protocadherinα family expression.
European Journal of Neuroscience. 2004 Dec 2; 20(11): 2843-2847. view in PubMed
Murata, Y., Hamada, S., Morishita, H., Mutoh, T., Yagi, T.
Interaction with Protocadherin-g regulates the cell-surface expression of Protocadherin-α.
Journal of Biological Chemistry. 2004 Nov 19;279(47): 49508-49516. view in PubMed
Tada, M., Senzaki, K., Tai, Y., Morishita, H., Tanaka, Y., Murata, Y., Ishii, Y., Asakawa, S., Shimizu, N., Sugino, H., Yagi, T.
Genomic organization and transcripts of the zebrafish Protocadherin genes.
Gene. 2004 Oct 13; 340(2):197-211. view in PubMed
Morishita, H., Makishima, T., Kaneko, C., Lee, YS., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K., Nakayama, KI.
Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice.
Biochemical and Biophysical Research Communications. 2001 Jun 1; 284(1):142-9. view in PubMed
